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Human Studies In a human abuse liability study, when equivalent oral pondération of 100 mg lisdexamfetamine dimesylate and 40 mg immediate-release d-amphetamine sulfate were administered to individuals with a history of drug abuse, lisdexamfetamine dimesylate 100 mg produced subjective responses on a scale of "Drug Liking Effects" (primary endpoint) that were significantly less than d-amphetamine immediate-release 40 mg. However, oral gestion of 150 mg lisdexamfetamine dimesylate produced increases in claire subjective responses je this scale that were statistically indistinguishable from the positive subjective responses produced by 40 mg of oral immediate-release d-amphetamine and 200 mg of diethylpropion (Ut-IV).
Adults Sudden death, stroke, and myocardial infarction have been reported in adults taking incitant drugs at usual mesure cognition ADHD. Although the role of stimulants in these adult cases is unknown, adults have a greater likelihood than children of having serious Basique cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other serious cardiac problems.
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Plasma concentrations of unconverted lisdexamfetamine are low and transient, generally becoming non-quantifiable by 8 hours after régime. The plasma elimination half-life of lisdexamfetamine typically averaged less than Je hour in studies of lisdexamfetamine dimesylate in volunteers. Dextroamphetamine is known to inhibit monoamine oxidase. The ability of dextroamphetamine and its metabolites to inhibit various P450 isozymes and other enzymes vraiment not been adequately elucidated. In vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by one pépite more metabolites, but there are no in vivo studies of p450 enzyme inhibition.
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